METABOLIK SINDROM HOLATIDAGI ONALARDAN TUG‘ILGAN AVLODLAR YURAGINING MORFOLOGIK VA MORFOMETRIK O‘ZGARISHLARI
Keywords:
metabolik sindrom, avlod yuragi, miokard, postnatal ontogenez, morfometriya, kardiomiotsit, interstitsial fibroz, perivaskulyar o‘zgarishlar, yurak klapanlari.Abstract
Ushbu tezisda tajribaviy metabolik sindrom chaqirilgan ona kalamushlardan tug‘ilgan avlodlar yuragining postnatal ontogenez davridagi morfologik va morfometrik o‘zgarishlari tahlil qilindi. Tadqiqotda ona organizmidagi metabolik buzilishlarning avlod yuragi miokardi, qon tomirlari, biriktiruvchi to‘qima stromasi va klapan apparatining shakllanishiga ta’siri baholandi. Tajriba modelida yuqori yog‘li va yuqori uglevodli ratsiondan foydalanilib, metabolik sindrom holati shakllantirildi. Nazorat va tajriba guruhlaridan olingan avlodlarning yurak to‘qimalari postnatal rivojlanishning turli muddatlarida gistologik va morfometrik usullar yordamida o‘rganildi. Aniqlanishicha, metabolik sindrom sharoitida rivojlangan avlodlarda yurak morfogenezi fiziologik yo‘nalishdan chetga chiqib, miokardning yetilishi sekinlashishi, kardiomiotsitlar tuzilishining o‘zgarishi, interstitsial va perivaskulyar sohalarning kengayishi, kollagen tolalarining ortiqcha to‘planishi hamda yurak klapanlari stromasida morfometrik o‘zgarishlar bilan namoyon bo‘ladi. Ushbu o‘zgarishlar postnatal davr davomida saqlanib, yosh ortishi bilan kuchayish tendensiyasini ko‘rsatadi. Olingan natijalar ona organizmidagi metabolik buzilishlar avlod yurak-qon tomir tizimining strukturaviy shakllanishiga uzoq muddatli ta’sir ko‘rsatishi mumkinligini ko‘rsatadi.
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Bu variantda asosiy natijalar aynan siz yuborgan dissertatsiya materiallaridagi ko‘rsatkichlar bilan bog‘langan, xususan 7–60 kunlik kuzatuv, kardiomiotsit o‘lchamlari, interstitsial/perivaskulyar maydonlar va klapanlardagi o‘zgarishlar kiritildi.
Agar uni Word’da 14-shrift, 1,5 interval bilan joylashtirsangiz, matnni 4 betga yaqin ilmiy tezis hajmida berish mumkin.
