TUBERCULOSIS
Keywords:
Tuberculosis, Mycobacterium tuberculosis, infeksiya, granuloma, immunitet, o‘pka zararlanishi, yo‘tal, gemoptiziya, diagnostika, radiologiya, bakteriologik tekshiruv, molekulyar diagnostika, kimyoterapiya, dori vositalariga chidamlilik, profilaktika.Abstract
Ushbu maqolada Tuberculosis kasalligining etiologiyasi, patogenezi, klinik kechishi hamda diagnostika va davolash tamoyillari keng yoritilgan. Tuberkulyoz bugungi kunda global miqyosda dolzarb muammo bo‘lib, uning tarqalishiga ijtimoiy-iqtisodiy omillar, immunitetning pasayishi va migratsiya jarayonlari sezilarli ta’sir ko‘rsatadi.
Maqolada kasallikning rivojlanish mexanizmlarida immun tizimning o‘rni, granuloma hosil bo‘lish jarayoni va Mycobacterium tuberculosis ning biologik xususiyatlari tahlil qilingan. Shuningdek, klinik belgilar — uzoq davom etuvchi yo‘tal, gemoptiziya, tana vaznining kamayishi va kechki terlash kabi simptomlar ilmiy asosda bayon etilgan.
Tadqiqotda zamonaviy diagnostika usullari, jumladan bakteriologik, radiologik va molekulyar-genetik tekshiruvlarning ahamiyati ko‘rsatib o‘tilgan. Davolash jarayonida esa kombinatsiyalangan kimyoterapiya, dori vositalariga chidamli shakllar muammosi va profilaktika choralariga alohida e’tibor qaratilgan.
References
1. World Health Organization. Global Tuberculosis Report 2023. Geneva: WHO; 2023
2. Kumar, V., Abbas, A. K., & Aster, J. C. Robbins & Cotran Pathologic Basis of Disease. 10th Edition. Philadelphia: Elsevier, 2021.
3. Zumla, A., et al. Tuberculosis. New England Journal of Medicine, 2013; 368:745–755.
4. Raviglione, M., et al. Tuberculosis: Current Concepts and Treatment Strategies. The Lancet, 2012; 379: 1202–1214.
5. Frieden, T. R., et al. Tuberculosis Control in the Era of Multidrug Resistance. New England Journal of Medicine, 2003; 348: 1979–1989.
6. Park, K. Park’s Textbook of Preventive and Social Medicine. 26th Edition. Jabalpur: Banarsidas Bhanot, 2021.
7. American Thoracic Society / CDC / Infectious Diseases Society of America. Treatment of Tuberculosis. Am J Respir Crit Care Med, 2016; 194: 1–26.
