SHAXSIYLASHTIRILGAN TIBBIYOT: GENETIK MA’LUMOTLAR ASOSIDA INDIVIDUAL DAVOLASHNING ZAMONAVIY IMKONIYATLARI VA ISTIQBOLLARI
Keywords:
shaxsiylashtirilgan tibbiyot, genetik ma’lumot, farmakogenomika, genetik test, individual davolash, biomarker, genomika.Abstract
Mazkur maqolada shaxsiylashtirilgan tibbiyotning zamonaviy tibbiyotdagi o‘rni hamda genetik ma’lumotlar asosida individual davolash imkoniyatlari tahlil qilingan. Shaxslar o‘rtasidagi genetik farqlar kasalliklarning rivojlanishi, dori vositalarining samaradorligi va nojo‘ya ta’sirlariga ta’sir ko‘rsatishi mumkin. Maqolada farmakogenomika, genetik testlar, zamonaviy sekvenslash texnologiyalari va molekulyar biomarkerlarning individual davolashni tanlashdagi ahamiyati yoritilgan. Shuningdek, shaxsiylashtirilgan tibbiyotni klinik amaliyotga joriy etishning afzalliklari, mavjud muammolari va istiqbolli yo‘nalishlari ko‘rib chiqilgan.
References
1. O‘zbekiston Respublikasi Sog‘liqni saqlash vazirligi. Sog‘liqni saqlash tizimida zamonaviy tibbiy texnologiyalarni joriy etish bo‘yicha uslubiy materiallar. — Toshkent.
2. O‘zbekiston Respublikasi Prezidentining **“O‘zbekiston Respublikasida biotexnologiyalarni rivojlantirish va biotexnologik mahsulotlar ishlab chiqarishni kengaytirish chora-tadbirlari to‘g‘risida”**gi qarori. — Toshkent.
3. O‘zbekiston Respublikasi Innovatsion rivojlanish agentligi. Biotexnologiya, genomika va tibbiyot sohasidagi ilmiy-tadqiqot yo‘nalishlari bo‘yicha materiallar. — Toshkent.
4. Respublika ixtisoslashtirilgan gematologiya va qon quyish ilmiy-amaliy tibbiyot markazi. Molekulyar-genetik diagnostika va zamonaviy laboratoriya texnologiyalariga oid ilmiy-uslubiy materiallar. — Toshkent.
5. O‘zbekiston Respublikasi Fanlar akademiyasi. Genomika va bioinformatika yo‘nalishidagi ilmiy-tadqiqot materiallari. — Toshkent.
6. Amaro-Álvarez L., Cordero-Ramos J., Calleja-Hernández M.Á. Exploring the impact of pharmacogenetics on personalized medicine: A systematic review. // Farmacia Hospitalaria. — 2024. — Vol. 48, No. 6. — P. 299–309.
7. Abad-Santos F., Aliño S.F., Borobia A.M. et al. Developments in pharmacogenetics, pharmacogenomics, and personalized medicine. // Pharmacological Research. — 2024. — Vol. 200. — Article 107061.
8. Dash B., Shireen M., Pushpendra et al. A Comprehensive Review: Pharmacogenomics and Personalized Medicine Customizing Drug Therapy Based on Individual Genetics Profiles. // Chinese Journal of Applied Physiology. — 2024. — Vol. 40. — Article e20240011.
9. Caudle K.E., Klein T.E., Hoffman J.M. et al. Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process. // Current Drug Metabolism. — 2014. — Vol. 15, No. 2. — P. 209–217
10. Duarte J.D., Thomas C.D., Lee C.R. et al. Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, ADRB1, ADRB2, ADRA2C, GRK4, and GRK5 Genotypes and Beta-Blocker Therapy. // Clinical Pharmacology & Therapeutics. — 2024. — Vol. 116, No. 4. — P. 939–947.
11. Theken K.N., Lee C.R., Gong L. et al. Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C9 and Nonsteroidal Anti-Inflammatory Drugs. // Clinical Pharmacology & Therapeutics. — 2020. — Vol. 108, No. 2. — P. 191–200.
12. Kim S., Yun Y.M., Chae H.J. et al. Clinical Pharmacogenetic Testing and Application: Laboratory Medicine Clinical Practice Guidelines. // Annals of Laboratory Medicine. — 2017. — Vol. 37, No. 2. — P. 180–193.
13. Hertz D.L., Bousman C.A., McLeod H.L. et al. Recommendations for pharmacogenetic testing in clinical practice guidelines in the US. // American Journal of Health-System Pharmacy. — 2024. — Vol. 81, No. 16. — P. 672–683.
14. World Health Organization. Genomics. — Geneva: WHO.
15. Pharmacogenomics: Driving Personalized Medicine. // Pharmacogenomics and Personalized Medicine. — 2023.
